The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2016
Filed:
Sep. 26, 2013
Institut Pasteur, Paris, FR;
Instituto DE Investigaciones Biologicas Clemente Estable, Montevideo, UY;
Facultad DE Medicina, Universidad DE LA Republica, Montevideo, UY;
Centre National DE LA Recherche Scientifique, Paris, FR;
Luis Barbeito, Montevideo, UY;
Mariana Pehar, Middleton, WI (US);
Patricia Cassina, Montevideo, UY;
Pedro M. Alzari, Paris, FR;
INSTITUT PASTEUR, Paris, FR;
INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE, Montevideo, UY;
FACULTAD DE MEDICINA, UNIVERSIDAD DE LA REPUBLICA, Montevideo, UY;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
Abstract
The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that bind to these modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.