logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9320722 B1

PDFFull Text
Date of Patent:
Apr. 26, 2016

Filed:

Sep. 26, 2014

Regulators of aldehyde dehydrogenase aldh3a1 and related therapeutic methods

Applicant:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventor:

Thomas D. Hurley, Indianapolis, IN (US);

Assignee:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Attorney:

Quarles & Brady, LLP

Primary Examiner:

Patrick Lewis

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61K 31/145 (2006.01); A61K 45/06 (2006.01); A61K 31/167 (2006.01); A61K 31/63 (2006.01); A61K 31/635 (2006.01); A61K 31/4184 (2006.01); A61K 31/136 (2006.01); A61K 31/381 (2006.01); A61K 31/426 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/4468 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61K 31/553 (2006.01);
U.S. Cl.
CPC ...
A61K 31/145 (2013.01); A61K 31/136 (2013.01); A61K 31/167 (2013.01); A61K 31/381 (2013.01); A61K 31/4184 (2013.01); A61K 31/426 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/4468 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 31/553 (2013.01); A61K 31/63 (2013.01); A61K 31/635 (2013.01); A61K 45/06 (2013.01);
Abstract

Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.

Find Patent Forward Citations

Hurley, Thomas. (2016). Regulators of aldehyde dehydrogenase aldh3a1 and related therapeutic methods (U.S. Patent No. 9320722). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9320722

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…