The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Sep. 26, 2014
Applicant:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Inventor:
Thomas D. Hurley, Indianapolis, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61K 31/145 (2006.01); A61K 45/06 (2006.01); A61K 31/167 (2006.01); A61K 31/63 (2006.01); A61K 31/635 (2006.01); A61K 31/4184 (2006.01); A61K 31/136 (2006.01); A61K 31/381 (2006.01); A61K 31/426 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/4468 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61K 31/553 (2006.01);
U.S. Cl.
CPC ...
A61K 31/145 (2013.01); A61K 31/136 (2013.01); A61K 31/167 (2013.01); A61K 31/381 (2013.01); A61K 31/4184 (2013.01); A61K 31/426 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/4468 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 31/553 (2013.01); A61K 31/63 (2013.01); A61K 31/635 (2013.01); A61K 45/06 (2013.01);
Abstract
Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.