The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
Mar. 09, 2009
Applicants:
Raymond L. Page, Southbridge, MA (US);
Tanja Dominko, Southbridge, MA (US);
Inventors:
Raymond L. Page, Southbridge, MA (US);
Tanja Dominko, Southbridge, MA (US);
Assignee:
Worcester Polytechnic Institute, Worcester, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/70 (2006.01); A61P 7/00 (2006.01); A61P 35/00 (2006.01); A61P 3/10 (2006.01); A61P 25/28 (2006.01); A61K 35/12 (2015.01); A61P 1/16 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01); A61P 25/00 (2006.01); A61P 19/08 (2006.01); C12N 5/0775 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0662 (2013.01); C12N 2500/02 (2013.01); C12N 2501/115 (2013.01); C12N 2506/1307 (2013.01);
Abstract
De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The de-differentiation protocols described herein comprise culturing the differentiated cells with an amount of FGF2 to de-differentiate the cells. These de-differentiated cells may then be cultured and used for experimentation, amplification and clinical applications. The clinical applications include the use of the cells for tissue and cell based therapies.