The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2016
Filed:
Apr. 19, 2012
Hector F. Deluca, Deerfield, WI (US);
Margaret Clagett-dame, Deerfield, WI (US);
Lori A. Plum, Arena, WI (US);
Rafal Barycki, Madison, WI (US);
Hector F. DeLuca, Deerfield, WI (US);
Margaret Clagett-Dame, Deerfield, WI (US);
Lori A. Plum, Arena, WI (US);
Rafal Barycki, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
This invention discloses (20R) and (20S)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin Danalogs, and especially (20R)-25,26,27-trinor-24-(p-methylphenylsulfonate)-vitamin D, its biological activities, and pharmaceutical uses therefor. This compound exhibits relatively little calcemic activity and does not promote cellular differentiation of HL-60 leukemia cells, but rather kills the cells. This cell death activity is found in small cell lung carcinoma also, but not in prostate, bone or ovarian cancer cells. This compound thus causes specific cell death in the absence of changes in calcium levels and without general toxicity in an animal. Therefore it might serve as a useful therapy for treatment of some forms of cancer, such as leukemia and lung cancer.