The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2016
Filed:
Nov. 28, 2013
Astellas Pharma Inc., Tokyo, JP;
Toshio Kurosaki, Tokyo, JP;
Tsubasa Watanabe, Tokyo, JP;
Kazuhiko Ohne, Tokyo, JP;
Hiroki Ishioka, Tokyo, JP;
Eisuke Nozawa, Tokyo, JP;
Takeshi Hanazawa, Tokyo, JP;
Shunichiro Hachiya, Tokyo, JP;
Hiroshi Shibata, Tokyo, JP;
Yuji Koga, Tokyo, JP;
Ryo Mizoguchi, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
[Problem] A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided. [Means for Solution] It was found that imidazo[1,2-a]pyridine compounds having a carbamoyl group at the 3-position and a particular cyclic group at the 8-position via a methyleneoxy group, or a salt thereof have sGC activation, and are useful as active ingredients of pharmaceutical compositions for treating or preventing various sGC-related cardiovascular diseases, in particular, peripheral arterial diseases, intermittent claudication, critical limb ischemia, hypertension, and pulmonary hypertension, thereby completing the present invention.