The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Jun. 05, 2008
Applicants:
Joseph Schlessinger, Woodbridge, CT (US);
Irit Lax, Woodbridge, CT (US);
Satoru Yuzawa, Fukuoka, JP;
Yarden Opatowsky, Raa'nana, IL;
Yan Yang, Hamden, CT (US);
Inventors:
Joseph Schlessinger, Woodbridge, CT (US);
Irit Lax, Woodbridge, CT (US);
Satoru Yuzawa, Fukuoka, JP;
Yarden Opatowsky, Raa'nana, IL;
Yan Yang, Hamden, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); C07K 2316/96 (2013.01); C07K 2317/34 (2013.01); C07K 2317/77 (2013.01);
Abstract
The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.