The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2016
Filed:
Jun. 24, 2014
Applicant:
Fina Biosolutions, Llc, Rockville, MD (US);
Inventor:
Andrew Lees, Silver Spring, MD (US);
Assignee:
Fina BioSolutions LLC, Rockville, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C08B 37/02 (2006.01); C08B 37/00 (2006.01); C08H 1/00 (2006.01); A61K 39/095 (2006.01); A61K 39/145 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); A61K 39/00 (2013.01); A61K 39/095 (2013.01); A61K 39/145 (2013.01); A61K 47/48284 (2013.01); C08B 37/006 (2013.01); C08B 37/0021 (2013.01); C08H 1/00 (2013.01); A61K 2039/6087 (2013.01); A61K 2039/627 (2013.01);
Abstract
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.