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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9254337 B1

PDFFull Text
Date of Patent:
Feb. 09, 2016

Filed:

Jun. 24, 2014

Activation of polysaccharides via the cyanylating agent, 2-cyanopyridazine-3(2h)-one (2-cpo), in the preparation of polysaccharide/protein conjugate vaccines

Applicant:

Fina Biosolutions, Llc, Rockville, MD (US);

Inventor:

Andrew Lees, Silver Spring, MD (US);

Assignee:

Fina BioSolutions, LLC, Rockville, MD (US);

Attorney:

Remenick PLLC

Primary Examiner:

Eric Olson

Assistant Examiner:

Dale R Miller

Int. Cl.
CPC ...
A61K 47/48 (2006.01); C08B 37/02 (2006.01); C08B 37/00 (2006.01); C08H 1/00 (2006.01); A61K 39/095 (2006.01); A61K 39/145 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); A61K 39/00 (2013.01); A61K 39/095 (2013.01); A61K 39/145 (2013.01); A61K 47/48284 (2013.01); C08B 37/006 (2013.01); C08B 37/0021 (2013.01); C08H 1/00 (2013.01); A61K 2039/6087 (2013.01); A61K 2039/627 (2013.01);
Abstract

This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.

Find Patent Forward Citations

Lees, Andrew. (2016). Activation of polysaccharides via the cyanylating agent, 2-cyanopyridazine-3(2h)-one (2-cpo), in the preparation of polysaccharide/protein conjugate vaccines (U.S. Patent No. 9254337). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9254337

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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