The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2016
Filed:
Aug. 19, 2014
Korea University Research and Business Foundation, Seoul, KR;
Sfc Co., Ltd., Chungcheongbuk-do, KR;
Bong-Rae Cho, Seoul, KR;
Dong Eun Kang, Seoul, KR;
Chang Su Lim, Seoul, KR;
Ji Yeon Kim, Seoul, KR;
Eun Sun Kim, Seoul, KR;
Hoon Jai Chun, Seoul, KR;
Korea University Research and Business Foundation, Seoul, KR;
SFC Co. Ltd., Chungcheongbuk-do, KR;
Abstract
The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu) in vivo using the same. The two-photon probe according to the present disclosure can detect intracellular free copper(II) on for a long period of time with a penetration depth greater than 90 μm in living cells and tissues without the problems of mistargeting and photobleaching and can quantitatively estimate copper(II) on concentration in vivo using the ratio of blue emission intensity at 400-450 nm and red emission intensity at 550-650 nm.