The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 19, 2016

Filed:

Jul. 12, 2013
Applicant:

The Jackson Laboratory, Bar Harbor, ME (US);

Inventors:

Michael V. Wiles, Mount Desert, ME (US);

Robert Taft, Southwest Harbor, ME (US);

Assignee:

The Jackson Laboratory, Bar Harbor, ME (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); A01K 67/02 (2006.01); A01K 67/027 (2006.01); C12N 15/877 (2010.01); C12N 15/873 (2010.01);
U.S. Cl.
CPC ...
A01K 67/02 (2013.01); A01K 67/0271 (2013.01); A01K 67/0275 (2013.01); A01K 2207/12 (2013.01); A01K 2217/058 (2013.01); A01K 2217/15 (2013.01); A01K 2217/203 (2013.01); A01K 2217/206 (2013.01); A01K 2217/30 (2013.01); A01K 2227/10 (2013.01); A01K 2267/02 (2013.01); C12N 15/873 (2013.01); C12N 15/877 (2013.01); C12N 15/8775 (2013.01);
Abstract

Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein.


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