The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 12, 2016

Filed:

Jan. 16, 2014
Applicant:

Abbvie Inc., North Chicago, IL (US);

Inventors:

Itzcoatl A. Pla, Worcester, MA (US);

Joseph G. Matuck, Worcester, MA (US);

John C. Fann, Shrewsbury, MA (US);

Christof Schulz, Ayer, MA (US);

Nichole A. Roy, Worcester, MA (US);

David F. Bruton, Enfield, CT (US);

James McIntire, Castro Valley, CA (US);

Yu-hsiang D. Chang, Solana Beach, CA (US);

Thomas Seewoester, Simi Valley, CA (US);

Assignee:

AbbVie Inc., North Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C12N 5/00 (2006.01); C12N 5/073 (2010.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); C07K 16/00 (2013.01); C07K 16/244 (2013.01); C07K 16/2869 (2013.01); C12N 5/0031 (2013.01); C12N 5/0037 (2013.01); C12N 5/0603 (2013.01); C07K 2317/21 (2013.01); C12N 2500/24 (2013.01); C12N 2500/25 (2013.01); C12N 2500/30 (2013.01); C12N 2500/32 (2013.01); C12N 2500/50 (2013.01); C12N 2500/60 (2013.01); C12N 2500/74 (2013.01); C12N 2500/76 (2013.01); C12N 2500/90 (2013.01); C12N 2501/33 (2013.01); C12N 2510/02 (2013.01);
Abstract

The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.


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