The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2015
Filed:
Mar. 26, 2015
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Georg Jaeschke, Basel, CH;
Lothar Lindemann, Basel, CH;
Heinz Stadler, Basel, CH;
Eric Vieira, Basel, CH;
Assignee:
Hoffman-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/04 (2006.01);
U.S. Cl.
CPC ...
C07D 413/04 (2013.01);
Abstract
The present invention relates to ethynyl derivatives of formula I wherein It has now surprisingly been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) which show advantageous biochemical-, physicochemical- and pharmacodynamic-properties compared to compounds of prior art.