The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2015
Filed:
May. 21, 2014
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Richard H. Kimura, Menlo Park, CA (US);
Sanjiv S. Gambhir, Stanford, CA (US);
Benjamin J. Hackel, Edina, MN (US);
Robert Teed, Menlo Park, CA (US);
Bin Shen, Mountain View, CA (US);
Frederick T Chin, Sunnyvale, CA (US);
Zhen Cheng, Mountain View, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
Disclosed are peptides comprising a molecular scaffold portion and a loop portion that binds to integrin αβ. This integrin is expressed on pancreatic tumors, making the peptides useful as imaging agents, among other uses. The peptides showed single-digit nanomolar dissociation constants similar to antibodies used clinically for imaging and therapy. The peptides rapidly accumulated in αβ-positive tumors, which led to excellent tumor-to-normal contrast. The peptides are specific for the targeted integrin αβreceptors expressed on orthotopic pancreatic tumors and various xenografts used. Additionally, pharmacokinetic-stabilization strategies endowed knots with rapid renal clearance, which significantly reduced off-target dosing.