The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Dec. 20, 2013
Applicant:
New England Biolabs, Inc., Ipswich, MA (US);
Inventors:
Zhenyu Zhu, Beverly, MA (US);
Aine Quimby, Newton, NH (US);
Shengxi Guan, Stoneham, MA (US);
Dapeng Sun, Arlington, MA (US);
Yishu Huang, Shanghai, CN;
Xuhui Lai, Shanghai, CN;
Siu-hong Chan, Ipswich, MA (US);
Xianghui Li, Shanghai, CN;
Shuang-Yong Xu, Lexington, MA (US);
Chunhua Zhang, Zhenjiang, CN;
Assignee:
New England Biolabs, Inc., Ipswich, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C12Q 1/34 (2006.01); C12N 9/16 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/34 (2013.01); C12N 9/16 (2013.01); C12N 9/22 (2013.01); C12Q 1/68 (2013.01); G01N 2333/916 (2013.01); G01N 2333/922 (2013.01);
Abstract
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.