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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9199927 B1

PDFFull Text
Date of Patent:
Dec. 01, 2015

Filed:

Sep. 14, 2012

Guanidinobenzoic acid compound

Applicants:

Jiro Fujiyasu, Chuo-ku, JP;

Kazuhiko Ohne, Chuo-ku, JP;

Susumu Yamaki, Chuo-ku, JP;

Tomoyoshi Imaizumi, Chuo-ku, JP;

Takeshi Hondo, Chuo-ku, JP;

Keisuke Matsuura, Chuo-ku, JP;

Tomohki Satou, Chuo-ku, JP;

Satoshi Sasamura, Chuo-ku, JP;

Inventors:

Jiro Fujiyasu, Chuo-ku, JP;

Kazuhiko Ohne, Chuo-ku, JP;

Susumu Yamaki, Chuo-ku, JP;

Tomoyoshi Imaizumi, Chuo-ku, JP;

Takeshi Hondo, Chuo-ku, JP;

Keisuke Matsuura, Chuo-ku, JP;

Tomohki Satou, Chuo-ku, JP;

Satoshi Sasamura, Chuo-ku, JP;

Assignee:

Astellas Pharma Inc., Tokyo, JP;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

Golam M M Shameem

Int. Cl.
CPC ...
A61K 31/47 (2006.01); C07C 229/02 (2006.01); C07D 215/38 (2006.01); C07C 279/18 (2006.01); C07D 213/79 (2006.01); C07D 215/20 (2006.01); C07D 215/48 (2006.01); C07D 215/50 (2006.01); C07D 333/38 (2006.01); C07D 333/40 (2006.01); C07D 233/64 (2006.01); C07D 257/04 (2006.01); C07D 271/06 (2006.01); C07D 207/16 (2006.01); C07D 277/20 (2006.01); C07D 277/56 (2006.01); C07D 209/20 (2006.01); C07D 209/42 (2006.01); C07D 295/12 (2006.01); C07D 211/62 (2006.01); C07D 217/26 (2006.01); C07D 271/07 (2006.01); C07D 295/13 (2006.01);
U.S. Cl.
CPC ...
C07C 279/18 (2013.01); C07D 207/16 (2013.01); C07D 209/20 (2013.01); C07D 209/42 (2013.01); C07D 211/62 (2013.01); C07D 213/79 (2013.01); C07D 215/20 (2013.01); C07D 215/48 (2013.01); C07D 215/50 (2013.01); C07D 217/26 (2013.01); C07D 233/64 (2013.01); C07D 257/04 (2013.01); C07D 271/06 (2013.01); C07D 271/07 (2013.01); C07D 277/20 (2013.01); C07D 277/56 (2013.01); C07D 295/12 (2013.01); C07D 295/13 (2013.01); C07D 333/38 (2013.01); C07D 333/40 (2013.01); C07B 2200/07 (2013.01); C07C 2101/02 (2013.01); C07C 2101/14 (2013.01);
Abstract

[Problem] Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution] The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and as a result, they have found that a guanidinobenzoic acid compound has a trypsin inhibitory action, thereby completing the present invention. The guanidinobenzoic acid compound of the present invention can be used as an agent for preventing and/or treating renal disease as an agent which will substitute low-protein diet therapy, and an agent for preventing and/or treating trypsin-related diseases, for example, pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like.

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