The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2015

Filed:

Dec. 15, 2011
Applicants:

Andrew Fire, Stanford, CA (US);

Scott D. Boyd, Stanford, CA (US);

Jason Merker, Palo Alto, CA (US);

Kyunga Seo, Daejeon, KR;

Eleanor L. Marshall, Washington, DC (US);

Inventors:

Andrew Fire, Stanford, CA (US);

Scott D. Boyd, Stanford, CA (US);

Jason Merker, Palo Alto, CA (US);

Kyunga Seo, Daejeon, KR;

Eleanor L. Marshall, Washington, DC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C12P 19/34 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6874 (2013.01); C12P 19/34 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6881 (2013.01); C12Q 1/6869 (2013.01); C12Q 2600/106 (2013.01);
Abstract

Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion.


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