The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2015
Filed:
Mar. 10, 2011
Michael T. Migawa, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Charles Allerson, San Diego, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Punit P. Seth, Carlbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Michael T. Migawa, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Charles Allerson, San Diego, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Punit P. Seth, Carlbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Provided herein are novel 5'-(S)—CHsubstituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the furanose ring of each of the novel 5′-(S)—CHsubstituted bicyclic nucleosides includes a 2′ to 4′ bridging group. The 5′-(S)—CHsubstituted bicyclic nucleosides are expected to be useful for enhancing one or more properties of the oligomeric compounds they are incorporated into such as for example increasing the binding affinity. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.