The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Feb. 06, 2012
Bruce Blazar, Golden Valley, MN (US);
Carl June, Merion Station, PA (US);
Wayne R. Godfrey, Los Altos, CA (US);
Richard G. Carroll, Lansdowne, PA (US);
Bruce Levine, Cherry Hill, NJ (US);
James L. Riley, Downingtown, PA (US);
Patricia Taylor, St. Paul, MN (US);
Bruce Blazar, Golden Valley, MN (US);
Carl June, Merion Station, PA (US);
Wayne R. Godfrey, Los Altos, CA (US);
Richard G. Carroll, Lansdowne, PA (US);
Bruce Levine, Cherry Hill, NJ (US);
James L. Riley, Downingtown, PA (US);
Patricia Taylor, St. Paul, MN (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and culture-expanded isolated CD4CD25suppressor Treg cells for the prevention or suppression of immune reactions in a host, particularly in a human host, and including autoimmune responses. The resulting ex vivo culture-expanded Treg cells provide a sufficient amount of otherwise low numbers of such cells, having long term suppressor capability to permit therapeutic uses, including the preventing, suppressing, blocking or inhibiting the rejection of transplanted tissue in a human or other animal host, or protecting against graft vs host disease. Also provided are therapeutic and immunosuppressive methods utilizing the ex vivo culture-expanded Treg cells for human treatment, and high efficiency methods for research use.