The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Sep. 28, 2011
Kiyoshi Takayama, Sapporo, JP;
Tomoko Shimizu, Sapporo, JP;
Yuji Urushibata, Sapporo, JP;
Yukihiko Sugimoto, Kumamoto, JP;
Kiyoshi Takayama, Sapporo, JP;
Tomoko Shimizu, Sapporo, JP;
Yuji Urushibata, Sapporo, JP;
Yukihiko Sugimoto, Kumamoto, JP;
NB HEALTH LABORATORY CO., LTD., Sapporo-Shi, Hokkaido, JP;
Abstract
It is an object of the present invention to provide an antibody that binds to a human PGEreceptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGEreceptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.