Phenanthroindolizidine compound and nfκb inhibitor containing same as active ingredient

Abstract

A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, Rrepresents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; Rrepresents a hydroxyl group, or a lower alkyloxy group; Rrepresents a hydrogen atom, a lower alkyl group, or a halogen atom; Rrepresents a hydrogen atom or a lower alkyloxy group; Rrepresents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with Ror an isopropylidenedioxy group formed together with R; Rrepresents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with Ror an isopropylidenedioxy group formed together with R; Rrepresents a hydrogen atom or a lower alkyl group; and Rrepresents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R, R, Rand Rare hydrogen atoms, Rand Rare hydroxyl groups, and Rand Rare methoxy groups).