The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Jun. 04, 2010
Antonio Giordani, Pavia, IT;
Stefano Mandelli, Casatenovo, IT;
Francesca Porta, Milan, IT;
Matteo Ghirri, Milan, IT;
Lucio Claudio Rovati, Monza, IT;
Antonio Giordani, Pavia, IT;
Stefano Mandelli, Casatenovo, IT;
Francesca Porta, Milan, IT;
Matteo Ghirri, Milan, IT;
Lucio Claudio Rovati, Monza, IT;
ROTTAPHARM S.P.A., Milan, IT;
Abstract
The present invention relates to the solid state of 6-(1H-imidazol-1-yl)-2-phenylquinazoline (I) and therefore to novel crystalline forms of the base and of pharmaceutically acceptable salts and solvates thereof, and also to methods for preparing them, to the respective pharmaceutical formulations and to their therapeutic use. Compound (I) may be obtained as the free base in five different crystalline forms, three polymorphic forms and two hydrates. Some pharmaceutically acceptable salts of (I) that have physicochemical characteristics acceptable for pharmaceutical development were obtained, and the respective polymorphic forms and/or hydrates were characterized.