The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Aug. 06, 2004
Ellen Jessouroun, Rio de Janeiro, BR;
Ivna Alana Freitas Brasileiro Da Silveira, Rio de Janeiro, BR;
Renata Chagas Bastos, Rio de Janeiro, BR;
Carl E. Frasch, Rockville, MD (US);
Che-hung Robert Lee, Silver Spring, MD (US);
Ellen Jessouroun, Rio de Janeiro, BR;
Ivna Alana Freitas Brasileiro Da Silveira, Rio de Janeiro, BR;
Renata Chagas Bastos, Rio de Janeiro, BR;
Carl E. Frasch, Rockville, MD (US);
Che-Hung Robert Lee, Silver Spring, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Fiocruz, Rio de Janiero, BR;
Abstract
Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.