The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 20, 2015

Filed:

Oct. 26, 2010
Applicants:

Gerard Anne Nicolaas Van Veen, Waalre, NL;

Jacobus Peter Johannes Peters, Amsterdam, NL;

Pleun Dona, Veldhoven, NL;

Alan Frank DE Jong, Eindhoven, NL;

Inventors:

Gerard Anne Nicolaas Van Veen, Waalre, NL;

Jacobus Peter Johannes Peters, Amsterdam, NL;

Pleun Dona, Veldhoven, NL;

Alan Frank De Jong, Eindhoven, NL;

Assignee:

FEI Company, Hillsboro, OR (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 15/14 (2006.01); G01N 21/05 (2006.01); B01J 19/00 (2006.01); B01L 3/00 (2006.01); H01J 37/20 (2006.01); H01J 37/26 (2006.01); B01L 7/00 (2006.01);
U.S. Cl.
CPC ...
B01J 19/0093 (2013.01); B01L 3/502761 (2013.01); H01J 37/20 (2013.01); H01J 37/26 (2013.01); B01J 2219/0086 (2013.01); B01J 2219/0097 (2013.01); B01J 2219/00783 (2013.01); B01J 2219/00824 (2013.01); B01J 2219/00831 (2013.01); B01J 2219/00833 (2013.01); B01J 2219/00905 (2013.01); B01L 7/54 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0822 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0439 (2013.01); B01L 2400/0442 (2013.01); B01L 2400/0487 (2013.01); G01N 2021/058 (2013.01); H01J 2237/2004 (2013.01); Y10T 436/143333 (2013.01);
Abstract

A micro-reactor is provided for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor includes a first channel for containing the fluid and a second channel adjacent to the first channel. A gap connects the first channel and the second channel and a window transparent to the method of inspection is provided at the gap. A static or dynamic gradient, such as a gradient in concentration of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field, is applied across the gap, thereby causing the particles to cross the gap. By detecting a property of the particles upstream in the first channel and then applying a pressure burst over the channels when the property meets certain pre-set criteria, only selected particles can be placed in the gap.


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