The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2015
Filed:
Apr. 27, 2012
Adam Mullick, Carlsbad, CA (US);
Rosanne M. Crooke, Carlsbad, CA (US);
Mark J. Graham, San Clemente, CA (US);
Kenneth W. Dobie, Del Mar, CA (US);
Richard Lee, Oceanside, CA (US);
Adam Mullick, Carlsbad, CA (US);
Rosanne M. Crooke, Carlsbad, CA (US);
Mark J. Graham, San Clemente, CA (US);
Kenneth W. Dobie, Del Mar, CA (US);
Richard Lee, Oceanside, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.