The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Feb. 09, 2005
Charles Allerson, Carlsbad, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Anne B. Eldrup, Danbury, CT (US);
Muthiah Manoharan, Weston, MA (US);
Richard H. Griffey, Vista, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Charles Allerson, Carlsbad, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Anne B. Eldrup, Danbury, CT (US);
Muthiah Manoharan, Weston, MA (US);
Richard H. Griffey, Vista, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.