The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Jun. 23, 2008
Applicants:
Michal Minczuk, London, GB;
Monika A. Papworth, Cambourne, GB;
Aaron Klug, London, GB;
Inventors:
Assignee:
Medical Research Council, London, GB;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); A61K 38/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); C07K 2319/07 (2013.01); C07K 2319/095 (2013.01); C07K 2319/81 (2013.01);
Abstract
Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.