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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9133023 B1

PDFFull Text
Expired
Date of Patent:
Sep. 15, 2015

Filed:

Sep. 24, 2011

Nanopore sensor comprising a sub-nanometer-thick layer

Applicants:

Ming-sheng Xu, Hangzhou, CN;

Hongzheng Chen, Hangzhou, CN;

Gang Wu, Hangzhou, CN;

Minmin Shi, Hangzhou, CN;

Mang Wang, Hangzhou, CN;

Inventors:

Ming-Sheng Xu, Hangzhou, CN;

Hongzheng Chen, Hangzhou, CN;

Gang Wu, Hangzhou, CN;

Minmin Shi, Hangzhou, CN;

Mang Wang, Hangzhou, CN;

Assignee:

Zhejiang University, Hangzhou, CN;

Attorney:

Han IP Corporation

Primary Examiner:

Luan Van

Assistant Examiner:

Steven Rosenwald

Int. Cl.
CPC ...
G01N 27/453 (2006.01); B82Y 15/00 (2011.01); G01N 33/487 (2006.01); G01N 27/447 (2006.01);
U.S. Cl.
CPC ...
B82Y 15/00 (2013.01); G01N 33/48721 (2013.01); G01N 27/447 (2013.01);
Abstract

A nanopore sensor comprises second electrophoresis electrode or micropump, second fluidic reservoir, second micro-nanometer separation channel, substrate, sub-nanometer-thick functional layer, first micro-nanometer separation channel, first electrophoresis electrode or micropump, and first electrophoresis electrode or micropump that are sequentially assembled. An opening and a nanopore are provided through the substrate and the sub-nanometer-thick functional layer, respectively. A first electrode for measuring ionic current is provided in the first micro-nanometer separation channel, and a second electrode for measuring ionic current is provide in the second micro-nanometer separation channel. The present invention provides a simple method to prepare a sub-nanometer functional layer having a nanopore extending through the sub-nanometer-thick functional layer. The pore size is comparable to the spacing between two adjacent bases in a DNA strand required for single-base resolution sequencing. The shape of nanopore overcomes nucleotide conformation effect on the identification as bases translocate through the nanopore.

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Xu, Ming-Sheng. (2015). Nanopore sensor comprising a sub-nanometer-thick layer (U.S. Patent No. 9133023). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9133023

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