The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2015
Filed:
Jan. 13, 2012
Applicants:
Karin Henderika Maria Bessembinder, Echt, NL;
Dennis Heemskerk, Echt, NL;
Ben DE Lange, Echt, NL;
Inventors:
Assignee:
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V., Delft, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/06 (2006.01); C07D 413/12 (2006.01); C07D 419/12 (2006.01);
U.S. Cl.
CPC ...
C07D 405/06 (2013.01); C07D 413/12 (2013.01); C07D 419/12 (2013.01);
Abstract
The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.