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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9115196 B1

PDFFull Text
Expired
Date of Patent:
Aug. 25, 2015

Filed:

May. 20, 2013

Antibodies and immunotoxins that target human glycoprotein nmb

Applicants:

The United States of America As Represented BY the Secretary of Health, Rockville, MD (US);

Duke University, Durham, NC (US);

Inventors:

Chien-Tsun Kuan, Cary, NC (US);

Darell D. Bigner, Mebane, NC (US);

Ira H. Pastan, Potomac, MD (US);

Assignee:

Other;

Attorneys:

Banner & Witcoff, Ltd.

Sarah A. Kagan

Primary Examiner:

Hong Sang

Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07K 16/28 (2006.01); C12N 15/00 (2006.01); A61K 47/48 (2006.01); C07K 16/30 (2006.01); G01N 33/574 (2006.01); C07K 16/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 47/48438 (2013.01); C07K 16/1214 (2013.01); C07K 16/30 (2013.01); C12N 15/00 (2013.01); G01N 33/57484 (2013.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01);
Abstract

The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiforme cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells. The antibodies may be formed in cells transformed with an isolated nucleic acid encoding a polypeptide comprising an antibody heavy chain variable region ('VH') and an antibody light chain variable region ('VL'). Such nucleic acids are provided.

Find Patent Forward Citations

Kuan, Chien-Tsun. (2015). Antibodies and immunotoxins that target human glycoprotein nmb (U.S. Patent No. 9115196). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9115196

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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