The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Dec. 18, 2009
Carlos J. Bosques, Arlington, MA (US);
Jennifer Lynn Murphy, Marshfield, MA (US);
Sibel Nur Gunay, Chestnut Hill, MA (US);
Zachary Shriver, Winchester, MA (US);
Cuihua Liu, Belmont, MA (US);
Carlos J. Bosques, Arlington, MA (US);
Jennifer Lynn Murphy, Marshfield, MA (US);
Sibel Nur Gunay, Chestnut Hill, MA (US);
Zachary Shriver, Winchester, MA (US);
Cuihua Liu, Belmont, MA (US);
Momenta Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a glycan preparation from which sialic acids have been released; subjecting the sialidase-treated glycan preparation to a separation technique that separates glycans based on charge-to-mass ratio; and quantifying the charged products using at least one quantification standard.