The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2015

Filed:

Jun. 08, 2012
Applicants:

Peter G. Schultz, La Jolla, CA (US);

Lital Alfonta, Omer, IL;

Johnathan R. Chittuluru, San Diego, CA (US);

Alexander Deiters, Saleigh, NC (US);

Dan Groff, San Diego, CA (US);

Daniel Summerer, Mannheim, DE;

Meng-lin Tsao, Merced, CA (US);

Jiangyun Wang, Beijing, CN;

Ning Wu, Boston, MA (US);

Jianming Xie, Mountain View, CA (US);

Huaqiang Zeng, San Diego, CA (US);

Mohammad Seyedsayamdost, Newton, MA (US);

James Turner, San Diego, CA (US);

Inventors:

Peter G. Schultz, La Jolla, CA (US);

Lital Alfonta, Omer, IL;

Johnathan R. Chittuluru, San Diego, CA (US);

Alexander Deiters, Saleigh, NC (US);

Dan Groff, San Diego, CA (US);

Daniel Summerer, Mannheim, DE;

Meng-Lin Tsao, Merced, CA (US);

Jiangyun Wang, Beijing, CN;

Ning Wu, Boston, MA (US);

Jianming Xie, Mountain View, CA (US);

Huaqiang Zeng, San Diego, CA (US);

Mohammad Seyedsayamdost, Newton, MA (US);

James Turner, San Diego, CA (US);

Assignee:

The Scripps Research Institute, La Jolla, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/06 (2006.01); C12N 9/00 (2006.01); C12P 21/02 (2006.01); C12N 15/10 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/93 (2013.01); C12N 15/1058 (2013.01); C12P 21/00 (2013.01); C12P 21/02 (2013.01);
Abstract

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.


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