The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Mar. 15, 2013
Janssen Biotech, Inc., Horsham, PA (US);
John Chen, San Diego, CA (US);
Johan Fransson, San Diego, CA (US);
Natalie Fursov, Spring House, PA (US);
Damon Hamel, San Diego, CA (US);
Thomas Malia, Spring House, PA (US);
Galina Obmolova, Spring House, PA (US);
Tatiana Ort, Spring House, PA (US);
Michael Rycyzyn, Spring House, PA (US);
Michael Scully, Spring House, PA (US);
Raymond Sweet, Spring House, PA (US);
Alexey Teplyakov, Spring House, PA (US);
John Wheeler, Spring House, PA (US);
Juan Carlos Almagro, Brookline, MA (US);
Janssen Biotech, Inc., Horsham, PA (US);
Abstract
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.