The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Aug. 20, 2012
Makoto Hashimoto, Tokyo, JP;
Kazunari Sekiyama, Tokyo, JP;
Yoshiki Takamatsu, Tokyo, JP;
Masayo Fujita, Tokyo, JP;
Akio Sekigawa, Tokyo, JP;
Makoto Hashimoto, Tokyo, JP;
Kazunari Sekiyama, Tokyo, JP;
Yoshiki Takamatsu, Tokyo, JP;
Masayo Fujita, Tokyo, JP;
Akio Sekigawa, Tokyo, JP;
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, Tokyo, JP;
Abstract
The present invention was accomplished for the purpose of developing a method for effectively treating and/or preventing synucleinopathies, and is based on a discovery that an adiponectin receptor agonist suppresses α (alpha)-synuclein aggregation, tau phosphorylation and a decrease in proteasomal activity. The method of the present invention for treating and/or preventing neurodegenerative diseases includes a step of administering an effective dose of at least one effective element selected from a group consisting of: adiponectin as an adiponectin receptor agonist; a compound inducing expression of adiponectin; globular adiponectin; and a compound inducing expression of globular adiponectin. The present invention further provides a screening method of the adiponectin receptor agonist for treating and/or preventing neurodegenerative diseases.