The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
May. 30, 2012
RU Chih C. Huang, Baltimore, MD (US);
David Edward Mold, Baltimore, MD (US);
Jih RU Hwu, Hsinchu, CN;
Ming Hua Hsu, Tucheng, CN;
Szu Chun Wu, Hsinchu, CN;
Ru Chih C. Huang, Baltimore, MD (US);
David Edward Mold, Baltimore, MD (US);
Jih Ru Hwu, Hsinchu, CN;
Ming Hua Hsu, Tucheng, CN;
Szu Chun Wu, Hsinchu, CN;
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Novel compounds which are derivatives of tetra-O-methyl nordihydroguaiaretic acid (NDGA), as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof are provided. These NDGA derivatives have a nitroimidazole moiety and these derivatives show preferential toxicity to hypoxic cells as hypoxic cytotoxins. Their cytotoxicity toward hypoxic cells is a result of abstraction of hydrogen from target molecules by free radicals formed in the reduction of the nitro group. This makes the disclosed compounds an effective anti cancer drug because hypoxic cells are generally considered to be more resistant to anti cancer drugs than normal cells. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including hepatocellular carcinoma, breast cancer and prostate cancer, are also provided.