The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Oct. 01, 2013
Applicant:
Arrowhead Research Corporation, Pasadena, CA (US);
Inventors:
Antonin De Fougerolles, Cambridge, MA (US);
John L. Diener, Cambridge, MA (US);
Emma Hickman, Horsham, GB;
Gregory Hinkle, Cambridge, MA (US);
Stuart Milstein, Cambridge, MA (US);
Anne-Marie Pulichino, Cambridge, MA (US);
Andrew Griffin Sprague, Cambridge, MA (US);
Assignee:
Arrowhead Research Corporation, Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); C12N 15/85 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61K 31/713 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/344 (2013.01);
Abstract
The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.