The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Mar. 28, 2014
Applicant:
Alphavax, Inc., Research Triangle Park, NC (US);
Inventors:
Jon O. Rayner, Apex, NC (US);
Jonathan F. Smith, Cary, NC (US);
Bolyn Hubby, Chapel Hill, NC (US);
Elizabeth A. Reap, Durham, NC (US);
Assignee:
ALPHAVAX, INC., Research Triangle Park, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/005 (2006.01); A61K 39/21 (2006.01); C12N 7/00 (2006.01); A61K 39/193 (2006.01); A61K 39/295 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/21 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/5258 (2013.01); C12N 2740/16222 (2013.01); C12N 2740/16234 (2013.01); C12N 2770/36143 (2013.01); C12N 2770/36162 (2013.01); C12N 2840/203 (2013.01);
Abstract
The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.