The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Oct. 18, 2007
Steven C. Quay, Woodinville, WA (US);
James Mcswiggen, Bothell, WA (US);
Narendra K. Vaish, Kirkland, WA (US);
Mohammad Ahmadian, Bothell, WA (US);
Steven C. Quay, Woodinville, WA (US);
James Mcswiggen, Bothell, WA (US);
Narendra K. Vaish, Kirkland, WA (US);
Mohammad Ahmadian, Bothell, WA (US);
Marina Biotech, Inc., New York, NY (US);
Abstract
The present disclosure provides meroduplex (nicked or gapped) ribonucleic acid molecules (mdRNA) that decreases or silences target gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a target gene RNA. In addition, the meroduplex may have one or more modifications or substitutions, such as nucleotide base, sugar, terminal cap structure, internucleotide linkage, or any combination of such modifications. Also provided are methods of decreasing expression of a target gene in a cell or in a subject to treat a disease related to altered expression of a target gene.