The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Apr. 27, 2010
Applicants:
Nicholas Tonks, Huntington, NY (US);
Aftabul Haque, Stony Brook, NY (US);
Inventors:
Nicholas Tonks, Huntington, NY (US);
Aftabul Haque, Stony Brook, NY (US);
Assignee:
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); G01N 33/573 (2006.01); C07K 16/00 (2006.01); C07K 16/40 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2317/80 (2013.01); G01N 33/573 (2013.01); G01N 2333/9121 (2013.01); G01N 2500/04 (2013.01);
Abstract
Described herein are agents, including antibodies, antibody fragments, polypeptides and organic small molecules, that bind reversibly inactive PTP1B (designated herein in the alternative as PTP1B-SN or PTP1B-OX) and stabilize it (stabilize PTP1B-OX) in such a manner that they inhibit reactivation of reversibly oxidized, inactive PTP1B by reduction (by reducing agent) and have no substantial direct inhibitory effect on phosphatase activity/PTP1B activity (for example, as detectable in assays in vitro).