The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Dec. 23, 2009
Applicants:
Bernard Rees-smith, Cardiff, GB;
Jane Sanders, Cardiff, GB;
Jadwiga Furmaniak, Cardiff, GB;
Inventors:
Assignee:
RSR Ltd., Cardiff, South Glamorgan, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); C07K 2299/00 (2013.01); C07K 2316/95 (2013.01); C07K 2316/96 (2013.01); C07K 2317/21 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01);
Abstract
According to one aspect there is provided an isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity, wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.