The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Jun. 27, 2014
Applicant:
Inflarx Gmbh, Jena, DE;
Inventors:
Renfeng Guo, Ann Arbor, MI (US);
Niels Cristoph Riedemann, Jena, DE;
Yan Li, Bejing, CN;
Beifen Shen, Bejing, CN;
Assignee:
INFLARX GMBH, Jena, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 39/395 (2013.01); C07K 2316/96 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 14/00 (2013.01); C07K 14/47 (2013.01);
Abstract
The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.