The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2015
Filed:
May. 09, 2006
Stephen L. Buchwald, Newton, MA (US);
Artis Klapars, Edison, NJ (US);
Jon C. Antilla, Tampa, FL (US);
Gabriel E. Job, Ithaca, NY (US);
Martina Uhlenbrock, Berlin, DE;
Fuk Y. Kwong, Cambridge, MA (US);
Gero Nordmann, Boston, MA (US);
Edward J. Hennessy, Roslindale, MA (US);
Stephen L. Buchwald, Newton, MA (US);
Artis Klapars, Edison, NJ (US);
Jon C. Antilla, Tampa, FL (US);
Gabriel E. Job, Ithaca, NY (US);
Martina Uhlenbrock, Berlin, DE;
Fuk Y. Kwong, Cambridge, MA (US);
Gero Nordmann, Boston, MA (US);
Edward J. Hennessy, Roslindale, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods, such as the reaction of Z-X with C(L)(R)(R')in the present of a catalyst and a base, thereby forming C(Z)(R)(R′); wherein X represents I, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents H or a negative charge; catalyst comprises a copper atom or ion, and a ligand, wherein the ligand is an optionally substituted aryl alcohol, alkyl amine, 1,2-diamine, 1,2-aminoalcohol, 1,2-diol, imidazolium carbene, pyridine, or 1,10-phenanthroline; the ligand is a chelating ligand; and the base represents a Bronsted base; R represents H, optionally substituted alkyl, cycloalkyl, aralkyl, aryl, or heteroaryl; R′ represents independently for each occurrence H, alkyl, cycloalkyl, aralkyl, aryl, or heteroaryl, formyl, acyl, —COR″, —C(O)N(R), sulfonyl, —P(O)(OR″), —CN, or —NO; R″ represents independently for each occurrence optionally substituted alkyl, cycloalkyl, aralkyl, aryl, or heteroaryl; and C(R′)(R) taken together may represent nitrile.