The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 30, 2015

Filed:

Dec. 06, 2010
Applicants:

Joerg Berghausen, Lorrach, DE;

Prasad K Kapa, Parsippany, NJ (US);

Joseph Mckenna, Nazareth, PA (US);

Joel Slade, Flanders, NJ (US);

Raeann Wu, Pine Brook, NJ (US);

Zhengming Du, Parsippany, NJ (US);

Frank Stowasswer, Murg, DE;

Inventors:

Joerg Berghausen, Lorrach, DE;

Prasad K Kapa, Parsippany, NJ (US);

Joseph McKenna, Nazareth, PA (US);

Joel Slade, Flanders, NJ (US);

Raeann Wu, Pine Brook, NJ (US);

Zhengming Du, Parsippany, NJ (US);

Frank Stowasswer, Murg, DE;

Assignee:

Novartis AG, Basel, CH;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/506 (2006.01); A61K 31/505 (2006.01); C07D 413/12 (2006.01); C07D 403/12 (2006.01); C07D 239/28 (2006.01); C07D 239/48 (2006.01);
U.S. Cl.
CPC ...
C07D 239/48 (2013.01);
Abstract

The present technology provides novel anhydrous and hydrated crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea, amorphous and anhydrous crystalline polymorphs of its monophosphoric acid salt, and the hydrochloride salt, including its dihydrate. The present technology further provides methods for preparing the various forms, compositions containing them, and methods of treatment employing them.


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