The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Nov. 23, 2010
Applicants:
Ralf-holger Voss, Ingelheim, DE;
Theobald Matthias, Mainz, DE;
Inventors:
Ralf-Holger Voss, Ingelheim, DE;
Theobald Matthias, Mainz, DE;
Assignee:
JOHANNES GUTENBERG-UNIVERSITAT MAINZ, Mainz, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 14/725 (2006.01); C07K 14/435 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C12N 15/63 (2013.01); C07K 14/435 (2013.01); C07H 21/04 (2013.01);
Abstract
The invention relates to the rational mutagenesis of polypeptides of α/β T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific α/β T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.