The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Nov. 01, 2010
Vijay Ahire, Pune, IN;
Sachin Sasane, Pune, IN;
Amol Deshmukh, Pune, IN;
Krishnat Kumbhar, Pune, IN;
Akshat Bhatnagar, Pune, IN;
Devendra Verma, Pune, IN;
Rajesh Vyas, Pune, IN;
Girij Pal Singh, Pune, IN;
Nandu Bhise, Pune, IN;
Vijay Ahire, Pune, IN;
Sachin Sasane, Pune, IN;
Amol Deshmukh, Pune, IN;
Krishnat Kumbhar, Pune, IN;
Akshat Bhatnagar, Pune, IN;
Devendra Verma, Pune, IN;
Rajesh Vyas, Pune, IN;
Girij Pal Singh, Pune, IN;
Nandu Bhise, Pune, IN;
LUPIN LIMITED, Mumbai, Maharashtra, IN;
Abstract
The present invention provides a novel process for preparation of darunavir that involves reduction of [(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, of formula (5). The present invention also provides darunavir ethanolate of particle size wherein dis less than 130 μm, dis less than 30 μm, dis less than 10 μm and process for its preparation.