The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2015
Filed:
Sep. 14, 2012
Michael P. Belmares, San Jose, CA (US);
Jonathan David Garman, San Jose, CA (US);
Peter S. LU, Palo Alto, CA (US);
Michael W. Salter, Toronto, CA;
Michael Tymianski, Toronto, CA;
Michael P. Belmares, San Jose, CA (US);
Jonathan David Garman, San Jose, CA (US);
Peter S. Lu, Palo Alto, CA (US);
Michael W. Salter, Toronto, CA;
Michael Tymianski, Toronto, CA;
NoNO, Inc., , CA;
Abstract
The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide of an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.