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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9061055 B1

PDFFull Text
Date of Patent:
Jun. 23, 2015

Filed:

Feb. 12, 2009

Oncolytic adenovirus armed with therapeutic genes

Applicants:

Juan Fueyo, Houston, TX (US);

Candelaria Gomez-manzano, Houston, TX (US);

W.k. Alfred Yung, Houston, TX (US);

Charles A. Conrad, Spring, TX (US);

Frederick F. Lang, Jr., Houston, TX (US);

Inventors:

Juan Fueyo, Houston, TX (US);

Candelaria Gomez-Manzano, Houston, TX (US);

W.K. Alfred Yung, Houston, TX (US);

Charles A. Conrad, Spring, TX (US);

Frederick F. Lang, Jr., Houston, TX (US);

Assignee:

Board of Regentsm The University of Texas System, Austin, TX (US);

Attorney:

Parker Highland PLLC

Primary Examiner:

Robert M Kelly

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61K 38/17 (2006.01); A61K 38/50 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 38/18 (2006.01); A61K 45/06 (2006.01); A61K 35/761 (2015.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 38/177 (2013.01); A61K 38/50 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2710/10322 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); A61K 38/00 (2013.01); A61K 38/1891 (2013.01); A61K 45/06 (2013.01); A61K 35/761 (2013.01);
Abstract

The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.

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