The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2015

Filed:

Apr. 29, 2013
Applicants:

International Business Machines Corporation, Armonk, NY (US);

454 Life Sciences Corporation, Brandford, CT (US);

Inventors:

Yann Astier, White Plains, NY (US);

Venkat K. Balagurusamy, Suffern, NY (US);

Steven Lefkowitz, Branford, CT (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/00 (2006.01); G01N 27/447 (2006.01); G01N 33/48 (2006.01); C12Q 1/68 (2006.01); G01N 21/75 (2006.01); B01L 3/00 (2006.01); G01N 33/543 (2006.01); G01N 33/487 (2006.01); G01N 27/414 (2006.01); G01N 27/327 (2006.01);
U.S. Cl.
CPC ...
G01N 27/4473 (2013.01); C12Q 1/6806 (2013.01); G01N 2021/757 (2013.01); B01L 3/502753 (2013.01); C12Q 1/6869 (2013.01); G01N 33/54373 (2013.01); G01N 33/48721 (2013.01); C12Q 1/6841 (2013.01); C12Q 2521/101 (2013.01); B01L 3/5023 (2013.01); B01L 2400/086 (2013.01); B01L 2300/0816 (2013.01); G01N 27/414 (2013.01); G01N 33/54393 (2013.01); G01N 27/3271 (2013.01); G01N 33/5438 (2013.01); G01N 33/48 (2013.01);
Abstract

A nanopore device includes a multi-layer structure comprising a surface defining an aperture extending through the multi-layer structure, wherein at least the surface comprising a minimal diameter comprises a monosilane functionalized silicon dioxide having a silicon-oxygen-silicon bond, the monosilane functionalized silicon dioxide having the following structure: wherein n is an integer from 1 to 12; Rand Rare each independently a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, or a tert-butyl group; and Ris a chloride, a carboxylic acid group, an amine group, an amide group, a thiol group, an alcohol group, an acyl chloride group, an acyl bromide group, an acyl iodide group, an alkene group, an alkyne group, or a polyether group. Also disclosed are methods for making, wetting, and operating the nanopore device.


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