The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Feb. 02, 2004
Applicants:
Steven G. Williams, Cheshire, GB;
Robert L. Crombie, Melbourne, AU;
Kai S. Lipinski, Staffordshire, GB;
Alistair S. Irvine, Derbyshire, GB;
Inventors:
Steven G. Williams, Cheshire, GB;
Robert L. Crombie, Melbourne, AU;
Kai S. Lipinski, Staffordshire, GB;
Alistair S. Irvine, Derbyshire, GB;
Assignee:
EMD Millipore Corporation, Billerica, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 7/00 (2006.01); C12N 7/01 (2006.01); C12P 19/34 (2006.01); C12N 15/85 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 48/00 (2013.01); C12N 2830/46 (2013.01); A01K 2217/05 (2013.01); C12N 2800/108 (2013.01);
Abstract
The invention relates to improved genetic elements providing high levels of expression of operably-linked genes in a variety of tissues. In particular, fragments of unmethylated, CpG islands of less than 2 kb are shown to provide enhanced transgene expression and have advantages in terms of vector construction and cloning capacity.