The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2015
Filed:
Oct. 06, 2006
Applicants:
James A. Raleigh, Chapel Hill, NC (US);
David Y-w Lee, Cambridge, MA (US);
Xiaoshen Ji, Acton, MA (US);
Inventors:
James A. Raleigh, Chapel Hill, NC (US);
David Y-W Lee, Cambridge, MA (US);
Xiaoshen Ji, Acton, MA (US);
Assignee:
Natural Pharmacia International, Inc., Burlington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 49/10 (2006.01); A61K 51/04 (2006.01);
U.S. Cl.
CPC ...
A61K 49/10 (2013.01); A61K 51/0455 (2013.01); A61K 51/0459 (2013.01);
Abstract
The present invention incorporates weakly basic substituents (pKa about 8 or greater) such as pyrrolidine, piperidine, piperazine and azapane moieties in halogenated 2-nitromidazoles for the non-invasive detection of cellular hypoxia in normal and malignant tissues. The compounds of the invention can be used inF positron emission tomography,F magnetic resonance spectroscopy, andF magnetic resonance imaging.