The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Dec. 21, 2011
Shun-cheng LI, London, CA;
Xing LI, London, CA;
Courtney Voss, London, CA;
Satoshi Nakamura, Minato-ku, JP;
Tetsuo Fukuta, Minato-ku, JP;
Yusuke Okano, Minato-ku, JP;
Tomonori Shiotani, Minato-ku, JP;
Kouji Tamori, Minato-ku, JP;
Yu Otani, Minato-ku, JP;
Shun-Cheng Li, London, CA;
Xing Li, London, CA;
Courtney Voss, London, CA;
Satoshi Nakamura, Minato-ku, JP;
Tetsuo Fukuta, Minato-ku, JP;
Yusuke Okano, Minato-ku, JP;
Tomonori Shiotani, Minato-ku, JP;
Kouji Tamori, Minato-ku, JP;
Yu Otani, Minato-ku, JP;
THE UNIVERSITY OF WESTERN ONTARIO, London, CA;
JSR CORPORATION, Tokyo, JP;
Abstract
The present invention relates to immunoglobulin (Ig)-binding proteins with alkali-resistance properties. In one embodiment, the present invention provides for a variant of an Ig-binding protein, the variant comprising the Ig-binding protein having at least one asparagine residue substituted with a histidine, a serine, an aspartic acid or a threonine residue. The at least one substitution may confer to the variant Ig-binding protein an increased stability in alkaline solutions when compared to the wild-type Ig-binding. The present invention relates also to matrices for affinity separation of immunoglobulins comprising the Ig-binding proteins of the present invention, and to methods of using the Ig-binding proteins of the present invention to separate immunoglobulins from mixture compositions.